Scroll down to find case examples, descriptive text and links for the following categories of neurodegenerative disease:
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Bovine polioencephalomalacia
These slides are from the brain of a 3-month old male Holstein/Simmental cross with an acute onset of seizures, opisthotonos, and head pressing. On physical examination the animal was depressed, and the cranial nerve reflexes were sluggish. Several calves on the farm were showing similar clinical signs. One of these was submitted for diagnostic necropsy. The other calves were treated by the veterinarian and survived.
Examine the slide at the sub-gross level. Can you observe any abnormalities? Where are the changes located anatomically? Examine the histology image on low magnification to check your assessment. Is there a particular zone of pallor? What is the anatomical distribution of the pallor (gray matter, white matter, both)? At higher magnification what changes would you expect to find? What other etiologies could explain this pattern of necrosis? What crude diagnostic tool was used to highlight these changes? What do you think the veterinarian did to save the remaining calves?
Examine the slide at the sub-gross level. Can you observe any abnormalities? Where are the changes located anatomically? Examine the histology image on low magnification to check your assessment. Is there a particular zone of pallor? What is the anatomical distribution of the pallor (gray matter, white matter, both)? At higher magnification what changes would you expect to find? What other etiologies could explain this pattern of necrosis? What crude diagnostic tool was used to highlight these changes? What do you think the veterinarian did to save the remaining calves?
Prion diseases
Below are histolopathologic images taken from examples of scrapie, nvCJD, and Heidenhan's varient CJD, and supplemental materials on these and other prion diseases..
Papers on aspects of prion diseases
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Overview
Prion Neuroinvasion
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Kuru and CJD transmission similarities
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